Detection of lytic bone lesions is crucial in the workup for multiple myeloma and very often dictates the decision to start treatment. Personal history of a monoclonal gammopathy of undetermined significance mgus. Dec 22, 2014 multiple myeloma is a malignant disease characterised by proliferation of clonal plasma cells in the bone marrow and typically accompanied by the secretion of monoclonal immunoglobulins that are detectable in the serum or urine. Scribd is the worlds largest social reading and publishing site. Patients with multiple myeloma generally present with excess bone marrow plasma cells, osteolytic bone lesions, renal disease, and immunodeficiency 6, 7. Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. Pdf on jan 20, 2012, ajaz shah and others published multiple myeloma and dentistry find, read and cite all the research you need. Plasma cells make antibodies against infectious agents. In 2015, an estimated 28,850 new cases of multiple myeloma were. Multiple myeloma affects slightly more men than women. If you have multiple myeloma but arent experiencing any symptoms also known as smoldering multiple myeloma, you may not need. Unser jubilaums mmbulletin 2019 steht fur sie zum download bereit.
Multiple myeloma blood american society of hematology. Ppt multiple myeloma powerpoint presentation free to view. Figure 1 shows the distribution of the number of malignant immuneproliferative disease and multiple myeloma cases and asrs in males and fig. Jul 20, 2017 multiple myeloma is a malignancy of terminally differentiated plasma cells, and patients typically present with bone marrow infiltration of clonal plasma cells and monoclonal protein in the serum. The evolving role of transplantation in multiple myeloma. The year of cancer diagnosis ranged from 2008 to 2012, inclusive. Modern imaging techniques such as mri, pet, and ct offer superior detection of myeloma bone disease and extramedullary manifestations of. Multiple myeloma mm is a neoplastic plasma disorder that is characterized by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal protein in the blood or urine and associated organ dysfunction. Conventional radiography, despite decades of use, is often insufficient for detection of bone disease in multiple myeloma. Pdf european myeloma network guidelines for the management. Epidemiology, biology, and outcome in multiple myeloma patients in different geographical areas of the world. However, the growing use of ct, mri, and pet technology has led to earlier diagnosis of multiple myeloma, more accurate therapy assessment, and better prediction of patient outcome. These cancerous cells build up and eventually damage the body.
Multiple myeloma mm is the second most common hematologic malignancy, with an estimated 30,770 new cases and 12,770 deaths in 2018 in the united states, 1 and 38,928 new cases and 24,287 deaths in 2012 in europe. Multiple myeloma diagnosis and treatment mayo clinic. Radiography has been the imaging reference standard for decades. Mieloma multiple en una paciente joven medigraphic.
Pdf the european myeloma network provides recommendations for the management of the most common complications of multiple myeloma. Wholebody lowdose computed tomography and advanced. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Multiple myeloma is cancer of the plasma cell which helps fight off infection. Multiple myeloma myeloma myeloma cancer plasma cell. If youre experiencing symptoms, treatment can help relieve pain, control complications of the disease, stabilize your condition and slow the progress of multiple myeloma. Highlights vom 11th international myeloma workshop, kos, 25. The mvp is a form that can help you identify areas you want to learn more about and talk to your healthcare team about the things in your life that may affect your treatment plan.
If a brother, sister or parent has multiple myeloma, you have an increased risk of the disease. Increased understanding of the microenvironmental interactions between malignant plasma cells and the bone marrow niche, and their role in disease progression and. Jan 12, 2018 download pdf introduction multiple myeloma mm is a plasma cell dyscrasia characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. Jun 12, 2019 black people are about twice as likely to develop multiple myeloma as are white people. The epidemiology of multiple myeloma mm is an increasingly investigated field, with many controversies. Multiple myeloma is a malignancy of terminally differentiated plasma cells, and patients typically present with bone marrow infiltration of clonal plasma cells. Multiple mieloma dan pv free download as powerpoint presentation. A free powerpoint ppt presentation displayed as a flash slide show on id. Download the pdf esmomagnitude of clinical benefit scale clinical practice guidelines patient. It is synonymous with myeloma and plasma cell myeloma. But developing a personal strategy can help you manage the disease.
Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. Multiple myeloma is a neoplastic plasmacell disorder that is characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, monoclonal protein in the blood. Labardini mendez, eduardo cervera ceballos, carmen corrales alfaro, micaela balbuena martinez, arlette araceli barbosa ibarra, jose ramiro espinoza zamora, omar genaro lopez navarro, cristal medina perez, juan ojeda tovar, ana florencia ramirez ibarguen, silvia rivas vera, sergio arturo sanchez guerrero. Eligible metaanalyses were sought in pubmed adopting a predefined algorithm, without any restriction of publication. The multiple myeloma is a disorder characteri sed by a proliferation of. Fields or multiple myelomaall fields or multiple myelomamesh terms and. Lab testing for multiple myeloma helps to diagnose the condition, determine its severity and spread, monitor its progress, detect complications, and monitor the effectiveness of treatment. Download pdf introduction multiple myeloma mm is a plasma cell dyscrasia characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. Wholebody lowdose computed tomography and advanced imaging. Bone disease is the most frequent feature of multiple myeloma mm, occurring in approximately two thirds of patients at diagnosis and in nearly all patients during their disease. Multiple myeloma is the most common cause of primary malignancy in bones. International comparison of multiple myeloma incidence. Multiple myeloma is a malignant disease characterised by proliferation of clonal plasma cells in the bone marrow and typically accompanied by the secretion of monoclonal immunoglobulins that are detectable in the serum or urine. The bone marrow is the soft, spongy tissue found in the center of many bones where blood cells are produced.